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Use of oxidised regenerated cellulose (ORC) and collagen dressings (PROMOGRAN™ Protease Modulating Matrix and PROMOGRAN PRISMA™ Wound Balancing Matrix) to kick-start the treatment of chronic wounds

Luxmi Dhoonmoon, Jacqui Fletcher, Paul Chadwick, Claire Checkley, Caroline Dowsett, Claire Acton, Duncan Stang
The treatment of chronic, non-healing wounds is one of the biggest challenges faced by healthcare providers (Irving, 2019), costing the NHS £5.3 billion per annum (Guest et al, 2015). PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix have been shown to help stimulate healing and reduce the risk of a wound becoming hard-to-heal. A working group of key opinion leaders met in June 2019 to discuss the use of PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix to kick-start the treatment of chronic wounds, and to develop a decision pathway for clinical practice to support clinicians. The group’s recommendations on appropriate use are presented here.

Chronic wounds are a burden to patients and the NHS and are predicted to increase at a rate of 12% per year as a result of delayed healing (Guest et al, 2017a). Chronic wounds can have a profound impact on quality of life for patients, resulting in pain, feelings of isolation, reduced mobility, lack of personal hygiene and financial concerns, which in turn can affect adherence to treatment. Patients with chronic wounds have increased rates of hospitalisation and antibiotic usage compared to people without wounds and a small number have been shown to consume a disproportionate amount of resources (Guest et al, 2015), creating further-significant challenges to the health system.

The aims and objectives of the meeting were to:

  • Identify the challenges of managing chronic wounds in practice
  • Draw on clinical experience and evidence base for using PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix
  • Suggest a framework to develop a pathway for PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix aligned with the National Wound Care Strategy for venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs), which is currently under development.

Current challenges faced in wound care
A working group of key opinion leaders initially discussed the extent of the problem caused by chronic wounds, focusing on the importance of the patient’s perspective. Patient empowerment and self-care in wound management has continued to gain momentum, with patients now playing a central role in their own healthcare if they are able and willing, which has proven to be beneficial for both patient and clinician (Wounds International, 2016). In addition, the amount of involvement patients have in their care can impact the overall reduction in wound management costs (Kapp et al, 2012). 

Table 1 includes common challenges that can be frustrating for both the clinician and patient, which can contribute to wound healing rates.Other challenges include the lack of a cohesive multidisciplinary team (MDT), delays in care provision, variations in practice and establishing shared care plans. It is understood by healthcare professionals that there are challenges to service delivery due to external factors (e.g. budgets, geography) that may cause gold standard treatment to remain unachievable.
The group agreed that in order to anticipate these challenges and to optimise treatment early, good patient triage criteria and referral systems for gold standard treatment should be in place. For the care of patients with diabetic foot ulceration and venous leg ulceration, there are national guidelines that clinicians can follow; however, there is a need to work towards establishing and standardising care pathways in other chronic wound types.

It is important to acknowledge these challenges in practice, to prioritise patient experience, and to work as part of a MDT in order to optimise assessment and care. The MDT approach has been shown to be effective in promoting continuity of care (Kjaer et al, 2005; Harding, 2006). Patients who are encouraged to actively participate in their plan of care can be supported through education to allow them to self-manage (Wounds UK, 2015). Partnered with a structured treatment pathway, this approach has the potential to improve patient outcomes and reduce variation in practice.

First principles of care
The basic first principles of care therefore need to be implemented routinely (Box 1) and it is important for healthcare professionals to understand the importance of an accurate holistic assessment and know when a referral needs to be made to a specialist.

Assessment and referral
Current blockages in care restrict capability — these may include product availability, or skill gaps. For example, Guest et al (2017b) identified that the ankle brachial pressure index (ABPI) is often not performed on patients with lower limb ulceration. This may occur for many reasons including, lack of appropriate equipment, skill or confidence in carrying out the procedure, along with a perceived lack of time (hand-held doppler assessment can be perceived as time-consuming). Blockages can also occur due to patient refusal and non-adherence to treatment. Good leadership is required to address these challenges. The aim should be to help simplify the decision-making process, so that it is not always deferred to the senior nurse to make decisions or carry out certain diagnostic procedures. This can ultimately save time in the long-term, as correct diagnosis and management should improve overall healing rates. Appropriate onward referral should be seen as a sign of strength, not a sign of weakness. Many clinicians are anxious that they will be perceived as not knowing what they are doing or always seeking help if they make a referral – but an appropriate referral indicates good clinical knowledge and self-awareness. Nevertheless, before a referral is made, the basic first principles of wound care, including a thorough assessment, should be completed.

Good patient–clinician relationship
Healthcare systems can do more to create more effective patient-centred models of wound care. Ultimately, a good patient–clinician relationship enables provision of consistent delivery of care as the patient moves through services (Wounds UK, 2019). Maintaining clear communication with patients is important in order to maintain their confidence in their main care provider, it should be explained to them why they are being referred onwards and how this decision has been reached based on the gold standard care delivered so far. It is also helpful to discuss with the patient what the potential outcomes of the referral will be. 

Dressing selection/suitability
Dressing selection for the management of exudate remains one of the primary clinical challenges in wound management (Acton and Moyna, 2018). Selecting the most appropriate dressing to manage the symptom requires a good understanding of the disease aetiology and the dressing mode of action. Once an appropriate product has been selected it is important for regular reassessment to be carried out. A step-up and step-down approach should be followed, whereby the dressing is matched to the wound and the levels of exudate being produced. The timing of re-assessment is important as it allows management plans to be followed and for products to have an effect, while also being responsive to the patient experience. Selection of the most appropriate product can both reduce frequency of dressing change and reduce the wound-associated symptoms which challenge the patient (Bajjada, 2017).
Knowledge of the wound-healing process, previous clinical experience and an accurate wound diagnosis can aid healthcare professionals in selecting the most appropriate dressings for use, based on a sound rationale, which will provide an optimum wound-healing environment.

Framework for practice
Pathways have been shown to provide a framework to structure assessment and management (Greatrex-White and Moxey, 2013). They are an effective tool in standardising care, establishing safe practice and assisting healthcare professionals with decision-making. These pathways can prompt the clinician to consider if the wound is progressing as expected, the basic principles of wound care have been adhered to and if onward referral is required. When using a pathway it is essential to establish the patient’s objectives and to jointly set realistic expectations.

A Pathway for use in practice
The group devised a pathway to aid appropriate use of PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix in practice (Figure 1).

PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix are designed to provide an optimum wound-healing environment and to modify wound biochemistry by reducing excess protease activity and offer a kick-start to healing (Cullen and Ivins, 2010). PROMOGRAN™ Matrix may be used on chronic wounds without infection and stuck in inflammation phase, and that are at low risk of infection. PROMOGRAN PRISMA™ Matrix may be used on chronic wounds that are stuck in inflammation phase and may also be used when wound infection is evident and in conjuction with antimicrobial therapies to impede bacterial growth. PROMOGRAN PRISMA™ Matrix has been optimised so that it is not detrimental to fibroblasts, in-vitro, and has been shown to protect against infection in clinical studies (Gottrup et al, 2013). Table 2 shows the dressing composition and the indications for use.

One way to ensure good practice is to follow a standard framework for assessment, for example TIME: Tissue, Infection/Inflammation, Moisture balance, Edge advancement (Schultz et al, 2003). Within the TIME acronym, ‘I’ stands for infection or inflammation (Schultz et al, 2003). However, in most instances, the focus is on infection and the management of bacterial bioburden rather than inflammation, as this is less well understood or recognised. It is important to consider inflammation and its causes, and to differentiate this from infection, as signs can often overlap (Figure 2).

How PROMOGRAN™ matrix and PROMOGRAN PRISMA™ matrix work
Chronic wounds have been shown to contain elevated levels of inflammatory cytokines, free radicals and proteases; all of which can be damaging to wound healing. PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix have the ability to reduce harmful proteases, free radicals and remove excess metal ions, whilst simultaneously protecting matrix proteins and growth factors, which increases the formation of tissue, as the wound progresses towards healing.

Haemostasis is the first phase of wound healing – the body’s natural response to trauma, which occurs when the blood vessels constrict, and the platelets create substances that form a clot and subsequently pause bleeding. This is followed by inflammation, the second phase, which begins once the injured blood vessels have leaked transudate (fluid pushed through the capillary as a result of high pressure). It can be recognised from the presence of heat, redness, pain and swelling. During this phase, pathogens, bacteria and damaged cells are removed from the wound. During the inflammatory phase matrix metalloproteinases (MMPs) assist in the breakdown and clearance of damaged tissues and microbes. Their activity is well regulated by tissue inhibitors of matrix metalloproteases (TIMPs) and ceases as the wound moves into maturation. Chronic wounds that have become stuck in the inflammatory stage of wound healing may present clearly in some patients. For others, where the inflammatory response is inhibited or dampened, the usual signs or symptoms may be less apparent or indeed absent.

Wounds that do not progress beyond the inflammatory phase often demonstrate an increased activity of proteases such as MMPs and elastase, as well as the persistence of inflammatory cells (Leaper et al, 2012). There is also a down regulation of TIMP activity. It is important to note that inflammation may be caused by a number of non-infective, autoimmune diseases, such as systemic lupus erythematosus or arthritis. All chronic wounds have elevated levels of proteases and these include MMPs and elastase, which are affected by a number of factors, including patient and wound characteristics. MMPs are part of the larger family of metalloproteinase enzymes that play an important part in wound healing (Parks, 1999; Page-McCaw et al, 2007), along with the activity of elastase. It is well established that healing can only be achieved when the right amount of proteases are in the right place and for the right duration, in order to promote granulation tissue formation and stimulate wound healing. Once holistic assessment and best practice have been carried out and infection has been excluded, it is important for clinicians to consider why the wound is still failing to progress to healing and whether excess host proteases, such as MMPs and elastase, are the underlying cause.

Use of PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix is beneficial in managing the underlying biochemistry of chronic wounds. Along with this, these dressings are able to encourage the increase of new tissue formation by protecting positive factors such as matrix proteins and growth factors (Cullen and Ivins, 2010) and are supported by a body of high level clinical evidence, including randomised controlled trials. Guest et al (2018) showed that the treatment of DFUs using a collagen-containing dressing plus standard care, instead of standard care alone, has the potential to improve outcomes, but for less cost. Educational support should be provided to healthcare professionals before the introduction of PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix. The use of these dressings should be monitored in practice and outcomes of care measured. An evaluation of PROMOGRAN PRISMA™ Matrix in hard-to-heal chronic wounds is presented in case studies 1 and 2.

PROMOGRAN™ Matrix Family of wound matrix dressings provide an interactive wound therapy that transform into a soft, conformable, biodegradable gel in the presence of exudate, maximising contact with the wound bed and optimising moisture levels. The application of these dressings, along with accurate holistic assessment and the use of this new pathway, could help to decrease wound inflammation, restart healing in wounds that have stalled and dramatically improve outcomes in hard-to-heal wounds.

Conclusion
PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix should be considered when no progression is seen after 4 weeks of delivering best practice care, in order to kick-start healing in chronic wounds. The new proposed pathway for use in practice will help clinicians to identify a clear stop point of when these dressings should no longer be used, when to consider referral and when to re-assess and review the diagnosis, patient objectives and expectations. PROMOGRAN™ Matrix and PROMOGRAN PRISMA™ Matrix have the potential to stimulate healing and reduce the risk of a wound becoming hard-to-heal, which could lead to improved healing rates for both the patients and the NHS.

REFERENCES:

Acton C, Moyna C (2018) Collaborative working to evaluate clinician acceptability of a carboxymethyl cellulose dressing. Wounds UK 14(4): 78–83
Bajjada T (2017) Using a step-up, step-down approach to exudate management. JCN 31(2): 32–38
Cullen B, Ivins N (2010) PROMOGRAN™ & PROMOGRAN PRISMA™  Made Easy. Wounds International 1(3) Available at: https://www.woundsinternational.com/resources/details/PROMOGRAN™-and-PROMOGRAN™-prisma-made-easy  (accessed 19.03.2020)
Cutting KF, Harding KG (1994) Criteria for identifying wound infection. J Wound Care 3(4): 198–201
Dowsett C, Newton H (2005) Wound bed preparation: TIME in practice. Wounds UK 1(3): 58–70
Gottrup F,  Cullen BM, Karlsmark T et al (2013) Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment. Wound Repair Regen 21(2): 216–25
Gouin JP, Kiecolt-Glaser JK (2011) The impact of Psychological Stress on Wound Healing: Methods and Mechanisms. Immunol Allergy Clin North Am 31(1):  81–93
Greatrex-White S, Moxey H (2013) Wound assessment tools and nurses’ needs: an evaluation study. Int Wound J 12(Suppl 3): 293–301
Guest J, Ayoub N, McIlwraith et al (2015) Health economic burden that wounds impose on the National Health Service in the UK. BMJ 009283
Guest JF, Fuller GW, Vowden P (2017a) Venous leg ulcer management in clinical practice in the UK: Costs and outcomes. Int Wound J 15(1): 29–37
Guest JF, Vowden K, Vowden P (2017b) The health economic burden that acute and chronic wounds impose on an average clinical commissioning group/health board in the UK. J Wound Care 26(6): 292–303
Guest JF, Singh H, Vowden P (2018) Potential cost-effectiveness of using a collagen-containing dressing in managing diabetic foot ulcers  in the UK. J Wound Care  27(3): 136–44
Harding KG (2006) Trends in wound care – the development of a specialty. Int Wound J 3: 147
Irving S (2019) Managing chronic, nonhealing wounds stalled in the inflammatory phase: a case series using a novel matrix therapy, CACIPLIQ20. Br J Community Nurs 24(9): S33-S37
Kapp S, Miller C, Elder K (2012) The impact of providing product funding for compression bandaging and medical footwear on compression use, wound healing and quality of life. Int Wound J 9(5): 494–504
Kinmond K, McGee P, Gough S, Ashford R (2003) ‘Loss of self’: a psychosocial study of the quality of life of adults with diabetic foot ulceration. J Tissue Viability 13(2): 6–16
Kjaer ML, Sorensen LT, Karlsmark T et al (2005) Evaluation of the quality of venous leg ulcer care given in a multi-disciplinary specialist centre. J Wound Care 14: 145–50
Leaper DJ, Schultz G, Carville K et al (2012) Extending the TIME concept: what have we learned in the past 10 years? Int Wound J 9 (Suppl 2): 1–19
Llor C, Bjerrum L (2014) Antimicrobial resistance: risk associated with antibotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 5(6): 229–41
National Institute for Health and Care Excellence [NICE] (2014) Pressure Ulcers: Prevention and Management. Available at: https://www.nice.org.uk/guidance/cg179 (accessed 20.07.2019)
National Institute for Health and Care Excellence [NICE] (2015) Diabetic Foot Problems: Prevention and Management. Available at: https://www.nice.org.uk/guidance/ng19 (accessed 20.07.2019)
National Institute for Health and Care Excellence [NICE] (2017) Clinical Knowledge Summaries: Leg ulcer – Venous. Available at: https://cks.nice.org.uk/leg-ulcer-venous#!topicSummary (accessed 20.07.2019)
Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8(3): 221–33
Parks WC (1999) Matrix metalloproteinases in repair. Wound Rep Regen 7(6): 423–32
Schultz GS, Sibbald RG, Falanga V et al (2003) Wound bed preparation: a systematic approach to wound management. Wound Rep Regen 11(2): S1–28
Scottish Intercollegiate Guidelines Network [SIGN] (2010) Management of Chronic Venous Leg Ulcers. Available at: https://www.sign.ac.uk/assets/sign120.pdf (accessed 20.07.2019)
Siddiqui AR, Bernstein JM (2010) Chronic wound infection: Facts and controversies. Clin Dermatol 28(5): 519–26
Wounds International (2016) International Best Practice Statement: Optimising Patient Involvement in Wound Management. Available at: https://www.woundsinternational.com/resources/details/international-best-practice-statement-optimising-patient-involvement-in-wound-management (accessed 19.03.2020)
Wounds UK (2015) Best Practice Statement: Compression Hosiery (2nd edn.). Available at: https://www.wounds-uk.com/resources/details/compression-hosiery-second-edition (accessed )
Wounds UK (2019) Best Practice Statement: Addressing Complexities in the Management of Venous Leg Ulcers. Available at: https://www.wounds-uk.com/resources/details/best-practice-statement-addressing-complexities-management-venous-leg-ulcers (accessed 19.03.2020)
Wound Source (2016) 8 Signs of Wound Infection. Available at: www.woundsource.com/blog/8-signs-wound-infection (accessed 16.08.2019)
World Union of Wound Healing Societies (2019) Wound Exudate: Effective Assessment and Management. A Consensus Document. London: Wounds International
Yazdanpanah L, Nasiri M, Adarvishi S (2015) Literature review on the management of diabetic foot ulcer. World J Diabetes 6: 37–53
Zhao R, Liang H, Clarke E, Jackson C, Xue M (2016) Inflammation in Chronic Wounds. Int J Mol Sci 17(12): 2085

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