This site is intended for healthcare professionals only
Share this article

Medication persistence in people with T2D differs between drug classes

By Colin Kenny, Editor – Diabetes Distilled


This study was a retrospective cohort analysis of a primary-care-based population from the Royal College of General Practitioners Research and Surveillance Centre cohort. The investigators identified 60,327 new prescriptions for oral diabetes medication in people living with type 2 diabetes between 1 January 2004 and 31 July 2015. They found that the majority (42,810 [70.9%]) of those had one or more oral medications prescribed, and they measured persistence with therapy in these individuals.

Metformin was found to have the longest median persistence. The likelihood of non-persistence compared with metformin was assessed using a hazard ratio (HR) analysis (the higher the number, the less likely the persistence with the agent): SGLT 2 inhibitors – HR, 1.04; sulfonylureas – HR, 1.20; dipeptidyl peptidase-4 inhibitors – HR, 1.43; thiazolidinediones – HR, 1.71; meglitinides – HR, 2.25; and alpha-glucosidase inhibitors – HR, 2.45. The analysis of SGLT 2 inhibitors was limited by the short duration of follow-up for this new class. Other factors associated with reduced medication persistence were female gender, younger age and non-white ethnicity. In summary, persistence was influenced by medication class and should be considered when initiating treatments.


To access the full publication, click here (log-in or purchase required)

Related content
Prevention of diabetic maculopathy: Trial of oral medication begins
Free for all UK & Ireland healthcare professionals

Sign up to all DiabetesontheNet journals


By clicking ‘Subscribe’, you are agreeing that are able to email you periodic newsletters. You may unsubscribe from these at any time. Your info is safe with us and we will never sell or trade your details. For information please review our Privacy Policy.

Are you a healthcare professional? This website is for healthcare professionals only. To continue, please confirm that you are a healthcare professional below.

We use cookies responsibly to ensure that we give you the best experience on our website. If you continue without changing your browser settings, we’ll assume that you are happy to receive all cookies on this website. Read about how we use cookies.