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HbA1c, diabetes and cognitive decline

By Colin Kenny, Editor – Diabetes Distilled


This study had 5189 participants (55.1% women; mean age, 65.6 years) with baseline HbA1c levels ranging from 15.9 to 126.3 mmol/mol (3.6–13.7%). The mean follow-up duration was 8.1 years, and the mean number of cognitive assessments was 4.9. Of this cohort, 1190 participants (22.9%) had prediabetes and 446 (8.6%) had type 2 diabetes. The investigators concluded that HbA1c levels were linearly associated with subsequent cognitive decline irrespective of diabetes status at baseline, and pointed to the importance of diabetes prevention and control to prevent cognitive decline.


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