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Neonatal death, stillbirth, congenital anomaly, large and small for dates babies and neonatal unit admission in diabetic pregnancies remain very high when compared to non-diabetic pregnancies. According to the latest National Pregnancy in Diabetes Audit, women with diabetes are not adequately prepared for pregnancy, with almost 90% not receiving risk-reducing pregnancy preparation as recommended by the National Institute for Health and Care Excellence. These findings have remained unchanged over the past 5 years.
Investigators wanted to find out whether exposure to metformin during the first trimester of pregnancy, for diabetes or other indications, increased the risk of congenital anomalies. They examined a European congenital anomaly registry (EUROmediCAT). They found 168 babies affected by a congenital anomaly (141 non-genetic and 27 genetic) who were exposed to metformin. No evidence was found for a significantly increased risk of all non-genetic congenital anomalies following exposure to metformin during the first trimester.
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