Professor John Buse
From the World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease, Naresh Kanumilli meets John Buse, Professor of Medicine at University of North Carolina Chapel Hill.
They discuss hypercortisolism and how common it is in people with type 2 diabetes and multiple long-term conditions, and John’s work on the CATALYST trial.
● When should we suspect?
● How to test cortisol levels.
● How can cortisol-directed therapy help?
● The “Ominous Octet”, or the “Noxious Nine”?
Professor Ralph deFronzo
Naresh discusses pioglitazone with Ralph deFronzo, Professor of Medicine at University of Texas Health San Antonio.
● Is there still a place for pioglitazone in type 2 diabetes management?
● Why Ralph advocates for triple therapy with an SGLT2 inhibitor, a GLP-1 RA and pioglitazone.
● Who should avoid pioglitazone?
Professor Jennifer Green
Naresh meets Jennifer B Green, Professor of Medicine at Duke University, to discuss the non-steroidal MRA finerenone and how we should be using it in primary care.
● Its potential benefits in people with type 2 diabetes and chronic kidney disease.
● Who to prioritise.
● Initiating finerenone and empagliflozin together: the CONFIDENCE trial.
● Hyperkalaemia and potassium monitoring.
Small but significant 12% increased risk of developing chronic cough compared to treatment with other second-line agents for type 2 diabetes.
8 Dec 2025