By Colin Kenny, GP, Dromore
This was a re-analysis of the Swedish Obese Subjects (SOS) study, where 4047 obese persons were enrolled and received either bariatric surgery or conventional therapy. Here, the participants were grouped into four BMI cohorts (<35, 35–40, 40–45 or ≥45 kg/m2) and also split by degree of weight change. The overall diabetes incidence was 7.1% in those with no weight change versus 1.5%, 0.0% and 0.5%, respectively, in those achieving minor, medium and major weight change (all differences P<0.01). Patients who had gained weight at the 2-year follow-up displayed a 6.4% diabetes incidence. Failure to achieve remission was more common in those with no weight change than in those who lost weight.
The SOS study showed that the incidence of type 2 diabetes was markedly lower in the people undergoing bariatric surgery than in the controls. This further analysis shows that a certain magnitude of weight reduction appears to be equally effective for all degrees of obesity when it comes to favorable effects on diabetes.
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