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Three-year effects of liraglutide 3 mg in obese adults with pre-diabetes

Results from a post hoc analysis of the phase 3a SCALE (Satiety and Clinical Adiposity – Liraglutide Evidence) trial show that people with obesity and prediabetes treated with liraglutide 3 mg are more likely to have consistent weight loss and improved blood glucose control over 3 years compared with those who receive placebo. The findings suggest that the glucagon-like peptide-1 receptor agonist may be an effective option for a population in whom weight loss does not typically last beyond 6 months.

In the trial, adults with prediabetes and obesity or who were overweight with comorbidities were randomised to receive liraglutide (n=1505) or placebo (n=749) for 160 weeks, both as an adjunct to a reduced-calorie diet and increased physical activity. Participants were categorised according to baseline BMI as overweight or class 1–3 obese. All four categories had consistent weight loss at 3 years compared with placebo, with mean weight loss ranging from 5.7% to 6.5% compared with 1.8% to 2.1% in placebo recipients.

The proportion of individuals who reverted to normal blood glucose levels on liraglutide was also similar across the four categories, ranging from 63% to 70%, and significantly greater compared with placebo (33–40%). In addition, improvements in a number of measures of glycaemic control were observed compared with placebo.

More details on the study can be read here.

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