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CV risk factors and cognitive decline in older people with T2D

In this study, investigators examined cardiovascular risk factors that predicted cognitive decline later in life in people with diabetes. They examined the roles of smoking, blood pressure, HbA1c, plasma glucose and cholesterol, and they used standardised cognitive assessments at follow-up. Increased smoking and poorer glycaemic control during the life-course were independently associated with accelerated late-life cognitive decline (with weaker findings for blood pressure).

by Colin Kenny, GP, Dromore

People with type 2 diabetes are at greater risk of cognitive decline in later life. Investigators used data from 831 participants in the Edinburgh Type 2 Diabetes Study (ET2DS) to test the associations of serum cholesterol, blood pressure, glycaemic control and smoking with late-life cognitive decline.

They concluded that smoking history, long-term exposure to raised blood pressure and poorer glycaemic control were independently associated with an accelerated late-life cognitive decline, short of dementia. The study provided strong observational evidence that smoking history, higher blood pressure and poorer glycaemic control are independently associated with accelerated late-life cognitive decline in people with type 2 diabetes.

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