By Colin Kenny, GP, Dromore
PAD is a significant and common complication of type 2 diabetes, but it is not clear what the relationship is between other vascular diseases and PAD. Researchers analysed data from 10,624 patients with type 2 diabetes free from baseline PAD in the ADVANCE clinical trial. They investigated a primary composite outcome associated with PAD, defined as PAD-induced death, peripheral revascularisation, lower-limb amputation or chronic ulceration.
In the 5-year follow up, 5.8% of the cohort developed PAD. After careful adjustment for risk factors, only microvascular disease was significantly associated with PAD, with the highest risk observed in participants with a history of macroalbuminuria and retinal photocoagulation therapy. Macrovascular disease did not predict the development of PAD.
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